Alzheimer’s Puzzle Pieces
While there is a race for a cure by pharmaceutical researchers, prevention of Alzheimer’s Disease (AD) has been on my mind.
In pursuit of some answers, I decided to brain-storm while mine was still working.
I’ve known many people who have died of AD, or complications therefrom. Some have been relatives, one was my bff, and watching the ravages of this modern-day plague is very frustrating. One reason is NASA is spending gazillions of dollars to find an alternative planet or Earth 2.0. Our United States Environmental Protection Agency seems to be our own worst enemy. And scientists are tripping all over themselves to make a buck in pharmacology, often wasting time independently instead of putting their resources together to literally Find A Cure.
I own some stock in a company called Anavex Life Sciences that I picked up just as I heard about it in the news and my friend was giving up her AD fight. I don’t normally buy stock but I needed to believe in something right then and this was a popular penny stock. I had some pennies and some prayers, so I bought in. Their main AD drug ‘candidate’ which is ‘novel’ (I’m using quotes because this is the way they talk in ‘pharma’ stock reports) is called Anavex2-73. Apart from some successful trials in early phases I don’t know anything about the company. It – I – we – suffered from a massive ‘pump & dump’ stock phenomenon that artificially increased the share price by enthusiastic stock holders who drove the company up way past it’s ‘market cap’ and then sold off at the high. Another group of players who came out of left field are ‘shorters’ who rode the wave while essentially betting that the stock would fall again and fail by borrowing shares they wouldn’t pay for until they ‘traded’ them to someone else. I still have my shares but have learned more than I wanted to know about the stock market. At last count the SEC was starting to investigate some personalities who used their influence in the media to profit from the pumps, dumps, and shorts they created.
Meanwhile, back at band camp, I’m wracking my brain to figure out what all of my family and friends who had AD all had in common. Smoking, drinking, gardening, lack of exercise or stressful occupations? So once I settled on gardening, I thought about the pesticides and insecticides they used and stored in their garage or potting rooms. They all ate the vegetables they grew in their gardens. They were/are all healthy except for the brain-thing. Can I put the blame on Monsanto and their ilk? Or the GMOs? Or global warming?
I decided to google the heck out of Alzheimer’s and see where it led and, to spare you the trip down the rabbit hole in which I fell, I came up with a theory.
Don’t laugh. I haven’t vetted it yet but wanted to jot it down for posterity before I forgot. I’ll research it more next time I’m in the mood.
Basically, coal tar was a toxic waste that mischievous European chemists were trying to find a use for. Some kid named Perkins tries to make coal tar into a waterproof/plastic coating to make wood seaworthy, and ends up creating a synthetic clothing dye by accident. It was indigo or mauve, I forget.
The point was that the world was running out of naturally occurring color molecules and there was a HUGE market for the Color of Royalty in ready-to-wear cotton and silk fancies.
Germany was the apothecary pharmaceutical capitol of the world back then so Perkins takes his dyestuff on the road. Turns out, Germany indeed needed the artificial coloring agent from coal tar – called aniline – to differentiate their pills for marketing. They didn’t care, or didn’t care to know, that aniline as benzene was highly toxic to humans. This was back when they were just discovering ammonia, quinine, alkaloids, strychnine, hydrochloride, mold and protozoa infections from newly charted colonies in tropical areas … so they had a lot on their plate. There was no FDA or oversight committee to impress so they started using coal tar for all kinds of color dying, from textiles to hair and eventually plastics (Yeah, the BPA kind).
Along comes Dr. Alzheimer who treats a 50 year old woman with an unknown mental ailment with unusual symptoms – like lack of short term memory. She was in an insane asylum and died 5 years later with the good doctor taking notes and eventually performing the postmortem on her brain. He noted unusual details about her brain and felt that mycotoxins were inhibiting her neurotransmitters with amyloid plaque – ironically he found this by using coal tar dye on the tangles.
I think the woman was exposed to coal tar dye either through direct contact of touching the mycotoxins while working with textiles in a factory, or in the air that had been heavily polluted from the mass production of it since she was born.
Did she have a weakened immune system that allowed the fungi to intrude past the blood-brain barrier, or was it carried to her brain via hyphae from her lungs and sinus passages? Did she have a DNA marker? Or was her DNA mutated in reaction to living amongst the poisons? Do individuals with Down’s Syndrome automatically have a genetic weakness for hydrocarbons? What other everyday products do we use that was haphazardly produced during the 1800’s without regard for consequences? It wasn’t just Germany; France and Switzerland were big players as well. They were fast and loose with their patents and everybody stole from everybody else to make a buck.
From what I have gathered, the AD epidemic exploded onto the scene during her era and after her death. If stats were being collected then, we’d know if the wealthier people were more apt to contract or develop AD – the ones who could afford clothing, robes, flags and linens of all colors.
We do know that it was more prevalent in industrialized cities and countries. We do know the FDA has had to ban several coal tar colors from the American marketplace, and we know other countries ban more than we allow our own citizens to digest.
If the early pharma companies in Germany had a hand in creating this disease, would they be quick to point that out and tell us not to take their colorful medicines anymore?
New information tells us that a mold or mildew is found in AD brains, and there are mad scientists out there who, as we speak, are trying to propagate even more and newly created fungi into our world’s food supplies.
RandomThoughtsRus NOTES: no particular order
Scientists increase worldwide fungi http://www.pbs.org/wgbh/nova/next/nature/more-food-with-microbes/
toxic waste from coal tar dye discovery
Oct 15 2015 Scientific Report http://www.nature.com/articles/srep15015
Is introducing more fungi to underdeveloped regions a good idea?
Formerly Down Syndrome Research and Treatment Foundation (DSRTF) and Research Down Syndrome (RDS)